The UTP-glucose-1-phosphate uridylyltransferase of Brucella melitensis inhibits the activation of NF-κB via regulating the bacterial type IV secretion system.
Identifieur interne : 000031 ( Main/Exploration ); précédent : 000030; suivant : 000032The UTP-glucose-1-phosphate uridylyltransferase of Brucella melitensis inhibits the activation of NF-κB via regulating the bacterial type IV secretion system.
Auteurs : Yucheng Zhou [République populaire de Chine] ; Zhaoyang Bu [République populaire de Chine] ; Jing Qian [République populaire de Chine] ; Yuening Chen [République populaire de Chine] ; Lianjiang Qiao [République populaire de Chine] ; Sen Yang [République populaire de Chine] ; Shipeng Chen [République populaire de Chine] ; Xinglong Wang [République populaire de Chine] ; Linzhu Ren [République populaire de Chine] ; Yanling Yang [République populaire de Chine]Source :
- International journal of biological macromolecules [ 1879-0003 ] ; 2020.
Abstract
UDP-glucose pyrophosphorylase (UGPase) is an important pyrophosphatase that reversibly catalyzes the synthesis of UDP-glucose during glucose metabolism. We previously found that the deletion of UGPase may affect structure, growth, the virulence of Brucella, and the activation of cellular NF-κB. However, the exact mechanism of activation of NF-κB regulated by Brucella UGPase is still unclear. Here, we found for the first time that UGPase can regulate the expression of virB proteins (virB3, virB4, virB5, virB6, virB8, virB9, virB10, and virB11) of type IV secretion system (T4SS) as well as effectors (vceC, btpA, btpB, ricA, bspB, bspC, and bspF) of Brucella by promoting the expression of ribosomal S12 protein (rpsL), BMEI1825, and quinone of 2,4,5-trihydroxyphenylalanine (topA) proteins, and further inhibits the activation of cellular NF-κB and affects the virulence of Brucella. Our findings provide new insights into the mechanism used by Brucella to escape the immune recognition, which is expected to be of great value in the designing of Brucella vaccines and the screening of drug targets.
DOI: 10.1016/j.ijbiomac.2020.08.134
PubMed: 32827613
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Sen" uniqKey="Yang S" first="Sen" last="Yang">Sen Yang</name><affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory for Molecular Biology of Special Economic Animals, Institute of Special Wild Economic Animals and Plants, Chinese Academy of Agricultural Sciences, Changchun 130112, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory for Molecular Biology of Special Economic Animals, Institute of Special Wild Economic Animals and Plants, Chinese Academy of Agricultural Sciences, Changchun 130112</wicri:regionArea><placeName><settlement type="city">Changchun</settlement><region type="province">Jilin</region><region type="groupement">Dongbei</region></placeName></affiliation></author><author><name sortKey="Chen, Shipeng" sort="Chen, Shipeng" uniqKey="Chen S" first="Shipeng" last="Chen">Shipeng Chen</name><affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory for Molecular Biology of Special Economic Animals, Institute of Special Wild Economic Animals and Plants, Chinese Academy of Agricultural Sciences, Changchun 130112, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory for Molecular Biology of Special Economic Animals, Institute of Special Wild Economic Animals and Plants, Chinese Academy of Agricultural Sciences, Changchun 130112</wicri:regionArea><placeName><settlement type="city">Changchun</settlement><region type="province">Jilin</region><region type="groupement">Dongbei</region></placeName></affiliation></author><author><name sortKey="Wang, Xinglong" sort="Wang, Xinglong" uniqKey="Wang X" first="Xinglong" last="Wang">Xinglong Wang</name><affiliation wicri:level="1"><nlm:affiliation>Military Veterinary Institute, Academy of Military Medical Sciences, Changchun 130112, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Military Veterinary 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Plants, Chinese Academy of Agricultural Sciences, Changchun 130112</wicri:regionArea><placeName><settlement type="city">Changchun</settlement><region type="province">Jilin</region><region type="groupement">Dongbei</region></placeName></affiliation></author><author><name sortKey="Bu, Zhaoyang" sort="Bu, Zhaoyang" uniqKey="Bu Z" first="Zhaoyang" last="Bu">Zhaoyang Bu</name><affiliation wicri:level="1"><nlm:affiliation>Military Veterinary Institute, Academy of Military Medical Sciences, Changchun 130112, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Military Veterinary Institute, Academy of Military Medical Sciences, Changchun 130112</wicri:regionArea><placeName><settlement type="city">Changchun</settlement><region type="province">Jilin</region><region type="groupement">Dongbei</region></placeName></affiliation></author><author><name sortKey="Qian, Jing" sort="Qian, Jing" uniqKey="Qian J" first="Jing" last="Qian">Jing Qian</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Veterinary Medicine, Jiangsu Academy of Agricultural Sciences, Nanjing 210014, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Institute of Veterinary Medicine, Jiangsu Academy of Agricultural Sciences, Nanjing 210014</wicri:regionArea><wicri:noRegion>Nanjing 210014</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Yuening" sort="Chen, Yuening" uniqKey="Chen Y" first="Yuening" last="Chen">Yuening Chen</name><affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory for Molecular Biology of Special Economic Animals, Institute of Special Wild Economic Animals and Plants, Chinese Academy of Agricultural Sciences, Changchun 130112, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory for Molecular Biology of Special Economic Animals, Institute of Special Wild Economic Animals and Plants, Chinese Academy of Agricultural Sciences, Changchun 130112</wicri:regionArea><placeName><settlement type="city">Changchun</settlement><region type="province">Jilin</region><region type="groupement">Dongbei</region></placeName></affiliation></author><author><name sortKey="Qiao, Lianjiang" sort="Qiao, Lianjiang" uniqKey="Qiao L" first="Lianjiang" last="Qiao">Lianjiang Qiao</name><affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory for Molecular Biology of Special Economic Animals, Institute of Special Wild Economic Animals and Plants, Chinese Academy of Agricultural Sciences, Changchun 130112, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory for Molecular Biology of Special Economic Animals, Institute of Special Wild Economic Animals and Plants, Chinese Academy of Agricultural Sciences, Changchun 130112</wicri:regionArea><placeName><settlement type="city">Changchun</settlement><region type="province">Jilin</region><region type="groupement">Dongbei</region></placeName></affiliation></author><author><name sortKey="Yang, Sen" sort="Yang, Sen" uniqKey="Yang S" first="Sen" last="Yang">Sen Yang</name><affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory for Molecular Biology of Special Economic Animals, Institute of Special Wild Economic Animals and Plants, Chinese Academy of Agricultural Sciences, Changchun 130112, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory for Molecular Biology of Special Economic Animals, Institute of Special Wild Economic Animals and Plants, Chinese Academy of Agricultural Sciences, Changchun 130112</wicri:regionArea><placeName><settlement type="city">Changchun</settlement><region type="province">Jilin</region><region type="groupement">Dongbei</region></placeName></affiliation></author><author><name sortKey="Chen, Shipeng" sort="Chen, Shipeng" uniqKey="Chen S" first="Shipeng" last="Chen">Shipeng Chen</name><affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory for Molecular Biology of Special Economic Animals, Institute of Special Wild Economic Animals and Plants, Chinese Academy of Agricultural Sciences, Changchun 130112, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory for Molecular Biology of Special Economic Animals, Institute of Special Wild Economic Animals and Plants, Chinese Academy of Agricultural Sciences, Changchun 130112</wicri:regionArea><placeName><settlement type="city">Changchun</settlement><region type="province">Jilin</region><region type="groupement">Dongbei</region></placeName></affiliation></author><author><name sortKey="Wang, Xinglong" sort="Wang, Xinglong" uniqKey="Wang X" first="Xinglong" last="Wang">Xinglong Wang</name><affiliation wicri:level="1"><nlm:affiliation>Military Veterinary Institute, Academy of Military Medical Sciences, Changchun 130112, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Military Veterinary Institute, Academy of Military Medical Sciences, Changchun 130112</wicri:regionArea><placeName><settlement type="city">Changchun</settlement><region type="province">Jilin</region><region type="groupement">Dongbei</region></placeName></affiliation></author><author><name sortKey="Ren, Linzhu" sort="Ren, Linzhu" uniqKey="Ren L" first="Linzhu" last="Ren">Linzhu Ren</name><affiliation wicri:level="4"><nlm:affiliation>Jilin Provincial Key Laboratory of Animal Embryo Engineering, College of Animal Sciences, Jilin University, Changchun 130062, China. Electronic address: renlz@jlu.edu.cn.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Jilin Provincial Key Laboratory of Animal Embryo Engineering, College of Animal Sciences, Jilin University, Changchun 130062</wicri:regionArea><placeName><settlement type="city">Changchun</settlement><region type="province">Jilin</region><region type="groupement">Dongbei</region></placeName><orgName type="university">Université de Jilin</orgName><placeName><settlement type="city">Changchun</settlement><region type="province">Jilin</region></placeName></affiliation></author><author><name sortKey="Yang, Yanling" sort="Yang, Yanling" uniqKey="Yang Y" first="Yanling" last="Yang">Yanling Yang</name><affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory for Molecular Biology of Special Economic Animals, Institute of Special Wild Economic Animals and Plants, Chinese Academy of Agricultural Sciences, Changchun 130112, China; Jilin Academy of Agricultural Sciences, Changchun 130033, China. Electronic address: m18043213639@163.com.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory for Molecular Biology of Special Economic Animals, Institute of Special Wild Economic Animals and Plants, Chinese Academy of Agricultural Sciences, Changchun 130112, China; Jilin Academy of Agricultural Sciences, Changchun 130033</wicri:regionArea><placeName><settlement type="city">Changchun</settlement><region type="province">Jilin</region><region type="groupement">Dongbei</region></placeName></affiliation></author></analytic><series><title level="j">International journal of biological macromolecules</title><idno type="eISSN">1879-0003</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">UDP-glucose pyrophosphorylase (UGPase) is an important pyrophosphatase that reversibly catalyzes the synthesis of UDP-glucose during glucose metabolism. We previously found that the deletion of UGPase may affect structure, growth, the virulence of Brucella, and the activation of cellular NF-κB. However, the exact mechanism of activation of NF-κB regulated by Brucella UGPase is still unclear. Here, we found for the first time that UGPase can regulate the expression of virB proteins (virB3, virB4, virB5, virB6, virB8, virB9, virB10, and virB11) of type IV secretion system (T4SS) as well as effectors (vceC, btpA, btpB, ricA, bspB, bspC, and bspF) of Brucella by promoting the expression of ribosomal S12 protein (rpsL), BMEI1825, and quinone of 2,4,5-trihydroxyphenylalanine (topA) proteins, and further inhibits the activation of cellular NF-κB and affects the virulence of Brucella. Our findings provide new insights into the mechanism used by Brucella to escape the immune recognition, which is expected to be of great value in the designing of Brucella vaccines and the screening of drug targets.</div></front></TEI><pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">32827613</PMID><DateRevised><Year>2020</Year><Month>11</Month><Day>10</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1879-0003</ISSN><JournalIssue CitedMedium="Internet"><Volume>164</Volume><PubDate><Year>2020</Year><Month>Dec</Month><Day>01</Day></PubDate></JournalIssue><Title>International journal of biological macromolecules</Title><ISOAbbreviation>Int J Biol Macromol</ISOAbbreviation></Journal><ArticleTitle>The UTP-glucose-1-phosphate uridylyltransferase of Brucella melitensis inhibits the activation of NF-κB via regulating the bacterial type IV secretion system.</ArticleTitle><Pagination><MedlinePgn>3098-3104</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S0141-8130(20)34225-2</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.ijbiomac.2020.08.134</ELocationID><Abstract><AbstractText>UDP-glucose pyrophosphorylase (UGPase) is an important pyrophosphatase that reversibly catalyzes the synthesis of UDP-glucose during glucose metabolism. We previously found that the deletion of UGPase may affect structure, growth, the virulence of Brucella, and the activation of cellular NF-κB. However, the exact mechanism of activation of NF-κB regulated by Brucella UGPase is still unclear. Here, we found for the first time that UGPase can regulate the expression of virB proteins (virB3, virB4, virB5, virB6, virB8, virB9, virB10, and virB11) of type IV secretion system (T4SS) as well as effectors (vceC, btpA, btpB, ricA, bspB, bspC, and bspF) of Brucella by promoting the expression of ribosomal S12 protein (rpsL), BMEI1825, and quinone of 2,4,5-trihydroxyphenylalanine (topA) proteins, and further inhibits the activation of cellular NF-κB and affects the virulence of Brucella. Our findings provide new insights into the mechanism used by Brucella to escape the immune recognition, which is expected to be of great value in the designing of Brucella vaccines and the screening of drug targets.</AbstractText><CopyrightInformation>Copyright © 2020 Elsevier B.V. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Zhou</LastName><ForeName>Yucheng</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>State Key Laboratory for Molecular Biology of Special Economic Animals, Institute of Special Wild Economic Animals and Plants, Chinese Academy of Agricultural Sciences, Changchun 130112, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bu</LastName><ForeName>Zhaoyang</ForeName><Initials>Z</Initials><AffiliationInfo><Affiliation>Military Veterinary Institute, Academy of Military Medical Sciences, Changchun 130112, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Qian</LastName><ForeName>Jing</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Institute of Veterinary Medicine, Jiangsu Academy of Agricultural Sciences, Nanjing 210014, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Yuening</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>State Key Laboratory for Molecular Biology of Special Economic Animals, Institute of Special Wild Economic Animals and Plants, Chinese Academy of Agricultural Sciences, Changchun 130112, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Qiao</LastName><ForeName>Lianjiang</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>State Key Laboratory for Molecular Biology of Special Economic Animals, Institute of Special Wild Economic Animals and Plants, Chinese Academy of Agricultural Sciences, Changchun 130112, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yang</LastName><ForeName>Sen</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>State Key Laboratory for Molecular Biology of Special Economic Animals, Institute of Special Wild Economic Animals and Plants, Chinese Academy of Agricultural Sciences, Changchun 130112, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Shipeng</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>State Key Laboratory for Molecular Biology of Special Economic Animals, Institute of Special Wild Economic Animals and Plants, Chinese Academy of Agricultural Sciences, Changchun 130112, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Xinglong</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>Military Veterinary Institute, Academy of Military Medical Sciences, Changchun 130112, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ren</LastName><ForeName>Linzhu</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Jilin Provincial Key Laboratory of Animal Embryo Engineering, College of Animal Sciences, Jilin University, Changchun 130062, China. Electronic address: renlz@jlu.edu.cn.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yang</LastName><ForeName>Yanling</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>State Key Laboratory for Molecular Biology of Special Economic Animals, Institute of Special Wild Economic Animals and Plants, Chinese Academy of Agricultural Sciences, Changchun 130112, China; Jilin Academy of Agricultural Sciences, Changchun 130033, China. Electronic address: m18043213639@163.com.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>08</Month><Day>19</Day></ArticleDate></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>Int J Biol Macromol</MedlineTA><NlmUniqueID>7909578</NlmUniqueID><ISSNLinking>0141-8130</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Brucella melitensis</Keyword><Keyword MajorTopicYN="N">Nuclear factor-kappa enhancer-binding protein (NF-κB)</Keyword><Keyword MajorTopicYN="N">Type IV secretion system (T4SS)</Keyword><Keyword MajorTopicYN="N">UTP-glucose-1-phosphate uridylyltransferase (UGPase)</Keyword></KeywordList><CoiStatement>Declaration of competing interest The authors declare no competing interests. All authors have approved the final version of the manuscript.</CoiStatement></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>07</Month><Day>15</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2020</Year><Month>08</Month><Day>12</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>08</Month><Day>17</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>8</Month><Day>23</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>8</Month><Day>23</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>8</Month><Day>23</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32827613</ArticleId><ArticleId IdType="pii">S0141-8130(20)34225-2</ArticleId><ArticleId IdType="doi">10.1016/j.ijbiomac.2020.08.134</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>République populaire de Chine</li></country><region><li>Dongbei</li><li>Jilin</li></region><settlement><li>Changchun</li></settlement><orgName><li>Université de Jilin</li></orgName></list><tree><country name="République populaire de Chine"><region name="Jilin"><name sortKey="Zhou, Yucheng" sort="Zhou, Yucheng" uniqKey="Zhou Y" first="Yucheng" last="Zhou">Yucheng Zhou</name></region><name sortKey="Bu, Zhaoyang" sort="Bu, Zhaoyang" uniqKey="Bu Z" first="Zhaoyang" last="Bu">Zhaoyang Bu</name><name sortKey="Chen, Shipeng" sort="Chen, Shipeng" uniqKey="Chen S" first="Shipeng" last="Chen">Shipeng Chen</name><name sortKey="Chen, Yuening" sort="Chen, Yuening" uniqKey="Chen Y" first="Yuening" last="Chen">Yuening Chen</name><name sortKey="Qian, Jing" sort="Qian, Jing" uniqKey="Qian J" first="Jing" last="Qian">Jing Qian</name><name sortKey="Qiao, Lianjiang" sort="Qiao, Lianjiang" uniqKey="Qiao L" first="Lianjiang" last="Qiao">Lianjiang Qiao</name><name sortKey="Ren, Linzhu" sort="Ren, Linzhu" uniqKey="Ren L" first="Linzhu" last="Ren">Linzhu Ren</name><name sortKey="Wang, Xinglong" sort="Wang, Xinglong" uniqKey="Wang X" first="Xinglong" last="Wang">Xinglong Wang</name><name sortKey="Yang, Sen" sort="Yang, Sen" uniqKey="Yang S" first="Sen" last="Yang">Sen Yang</name><name sortKey="Yang, Yanling" sort="Yang, Yanling" uniqKey="Yang Y" first="Yanling" last="Yang">Yanling Yang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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